Detection and clinical observation of viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease

Abstract

Objective To analyze the viral infection in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD) and its clinical significance. Methods 350 patients with acute exacerbation of COPD were collected.The viral infection and clinical manifestations, pulmonary function and imaging features were detected and analyzed. Results A total of 104 patients with viral infection, the proportion was 29.7%.Single virus infection in 74 cases(71.2%), the highest proportion was FluB(19.2%) in pathogen type, followed by FluA(15.4%). Multiple virus infection in 30 cases(28.8%), the highest proportion was RSV+ FluB(11.5%). The virus infection in patients with sore throat(20.2% vs.6.9%), lung function grade(32.7% vs.20.3%), presence of pulmonary inflammatory lesions(57.7% vs.40.7) and the death rate(12.5% vs.0.8%) were significantly higher than those of the combined group of virus infection, the proportion of lung function was significantly lower than patients without viral infection, the differences were statistically significant(χ2=6.546, 5.477, 4.987, 4.124, 3.997, all P<0.05). The proportion of respiratory failure in patients with acute COPD infection was 86.5%, which was higher than 62.6% of patients without viral infection, the difference was statistically significant(χ2=19.837, P<0.05). Conclusion Acute exacerbation of COPD has a high proportion of virus infection, and the prognosis of patients is poor. Key words: Pulmonary disease, chronic obstructive; Viruses; Respiratory function tests; Infection