Abstract
The objective of the study is to prepare the nano particles of 5-fluorouracil with targeted delivery to the colon with enhancement of bioavailability and decrease the side effects of the drug. 5-Fluorouracil-loaded PLGA nanoparticles were developed by double solvent evaporation technique method. Characterization was carried out by determination of encapsulation efficiency (%), loss on Drying. The in-vitro drug release of drug 5- Fluorouracil was carried out for formulations (F1-F4), it is concluded that F4 was the best formulation which shows the most desired rate drug release and concluded that the polymer PLGA have a capacity of protection the drug in the GI and small intestinal Fluid hence, the maximum release of drug in the colonic region of large intestine.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
