Abstract
A general method of selective excitation design for shaped pulses and pulse sequences is presented, based on analysis of the derivatives of M + (Δω), where M + is the transverse magnetization and Δω is the resonance-offset frequency. We use this method to derive pulse sequences which suppress the solvent resonance at one offset frequency and produce uniform-phase and -amplitude excitation at another offset frequency. Two families of pulse sequences are presented: small-flip-angle asymmetric pulse sequences and large-flip-angle symmetric pulse sequences. Experimental application of the pulse sequences is given for observing 1H NMR resonances of carbonmonoxyhemoglobin and deoxyhemoglobin (deoxy-Hb) in aqueous solution and deoxy-Hb inside intact red blood cells.
Published Version
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