Design, Formulation, and Evaluation of Lisinopril Mucoadhesive Buccal Patches by Using the Combination of Natural Polymers

Abstract

The main objective of present investigation to formulate and evaluate mucoadhesive buccal patches of Lisinopril using solvent casting method. Sodiumalginate combined with Sodium carboxyl methyl cellulose, HPMC, and Carbopol934 in different proportions were used as a mucoadhesive polymer and Propyleneglycol used as a plasticizer as well as penetration enhancers. The formulated Buccal patches of Lisinopril were evaluated on the basis of Thickness, Weight uniformity, folding endurance, swelling Studies, Surface pH Determination, Percentage Moisture loss, Drug content Uniformity, Ex-Vivo Mucoadhesive strength, In Vitro Drug Release, Ex- vivo permeation study. By compatibility study there is no chemical interaction between drug and excipients used. All prepared buccal patches were transparent, smooth, consistent and flexible. The surface pH of all formulations was found to be almost in neutral pH and no mucosal irritation was expected. Among all the formulations, F6 showed maximum swelling index as 25.01%. The optimized formulation F6 also showed satisfactory, Mucoadhesive strength (5.1kg/cm2), drug content (98.75), and Ex-Vivo permeation (82.03%). In-Vitro drug release of optimised formulation (F6) was found to be 75.12 at the end of 8 hrs. Drug release mechanism was determined by plotting release data to Higuchi and Korsmeyer-Peppas model. All the formulations are best fitted to Korsmeyer-Peppas model and according to this model the drug releases from theses patches may be controlled by diffusion with super case-II transport.