Design, Development and Evaluation of Nanosponges Loaded Topical Gel for Rejuvenation of Skin

Abstract

The study aimed the development of nanosponges was the choice due to the numerous advantages of this novel technology over the others. Rutin was chosen as it has excellent antioxidant potential. The compatibility study was performed using Fourier transform infrared (FTIR) and there was no interaction found. The optimization study was brought off by Design expert software (version.13). Nanosponges were prepared by emulsion solvent diffusion method. The prepared sponges were brimmed in a night gel formulation for their suitable delivery to the skin. The prepared nanosponges were evaluated for various parameters such as particle size analysis, entrapment efficiency and zeta potential which were found in the acceptable limit. In-vitro permeation study was carried out using Franz-diffusion cell and the cumulative percent drug permeation was found to be 69 to 84.5% in 30 hours. A gel formulation was prepared using rutin-loaded nanosponges and studied for various parameters such as pH, viscosity, and extrudability for various combinations using NS-4. Ex-vivo drug diffusion study reveals that the night gel took 300 minutes for 78.26 to 94.16% permeation. The IC50 values of the flavonoid combination, NS-4 was found to be 54.70, 52.76, and 51.65 μg/mL in the different in-vitro models viz. DPPH, when compared to that of the standard ascorbic acid. Conclusively, the objective of delivery of rutin using nanosponges as carriers for the target delivery was achieved by NS-4 formulation and successfully delivered as night gel for skin rejuvenation.