Design and Evaluation of Transdermal Patches Containing Risperidone

Abstract

Transdermal drug delivery systems are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc. are intended to deliver a therapeutically effective amount of drug across the skin. In the present work, Transdermal drug delivery of Risperidone were formulated in different concentration (10%, 20% and 30%) of glycerine and polyethylene glycol 400 as plasticizer and a blend of two in different concentrations of polymers (PVPK30, HPMC, PVA and Eudragit RS 100) were formulated by solvent casting method. Drug polymer interaction study was carried out using FTIR and DSC studies. In this study the results indicates, as increase in the concentration of glycerine and Polyethylene glycol increases the diffusion rate of Risperidone patches. The physico-chemical parameters like weight variation, thickness, folding endurance. Percentage Flatness and Water vapour transmission of the Risperidone patches were evaluated. All the physico chemical parameters were found to be satisfactory. Risperidone patches formulated by using 30% glycerine 30% PEG400shows enhanced rate of diffusion than the patches prepared with 10% and 20% glycerine10% and 20% PEG400 respectively. Risperidone patches formulated with 20% glycerine 20% PEG400 had enhanced rate than the patches prepared with 10%glycerine/10% PEG400 respectively. Among polymers, combination of HPMC and Eudragit had enhanced diffusion rate than the combination of HPMC and PVPK30 in all formulations formulated by using glycerine as plasticizer. The polymers, combination of PVPK30 and Eudragit had enhanced diffusion rate than the combination of PVPK30 and PVA in all formulations formulated by using PEG400 as plasticizer. The Risperidone transdermal patches shows greater diffusion rate when formulated with higher concentration of plasticizer hence the 30% of glycerine and PEG 400 had shown a values higher than 20 and 10% glycerine and PEG 400. The kinetic study and mechanism for the diffusion of Risperidone transdermal patches obeys higuchi, peppas model. The correlation coefficient (R2) values were greater, indicating from the analysis of diffusion data as per above models. The T50 and T80 values for Risperidone patches formulated with glycerine and PEG 400 are exhibited good results. The SEM films indicating uniform distribution of the drug with polymers and plasticizers.