Abstract
The present research was aimed to formulate a soft and easy to handle transdermal patch consisting simple and cost effective monolithic polymeric film as an attempt to deliver Febuxostat transdermallyand overcome problems associated with its poor bioavailability and hepatic first pass metabolism. Transdermal patches of Febuxostat were prepared by solvent casting method. Prepared formulations were evaluated for various parameters tensile strength, thickness, folding endurance, % moisture content, % moisture uptake, % drug content, % elongation, In vitro drug release. Based on the evaluation of transdermal patches, concluded that the concept of transdermal drug delivery is a novel, nontoxic as well cost-effective technique for enhancing the aqueous solubility and bioavailability of the drug. It can be concluded that transdermal drug delivery works very simple in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Thus, overcome the adverse effects caused by oral route.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.