Design and Assessment of Boswellia Nanofibers for Diabetes Wound Healing

Abstract

Diabetic wounds present a major healthcare challenge because they frequently result in serious side effects and chronic, non-healing ulcers. The application of nanotechnology in the creation of sophisticated wound dressings has demonstrated encouraging outcomes in accelerating the healing of wounds. Particularly, nanofiber-based dressings have drawn interest because of their large surface area, porosity, and capacity to replicate the extracellular matrix, which creates the perfect surroundings for attachment of cells, growth, and differentiation. This review emphasizes the various materials and methods utilized in the preparation of nanofiber dressings, with a particular focus on their application in the treatment of diabetic wounds. Herbs and plant extracts are among the synthetic and natural polymers that have been added to nanofibers to improve their medicinal qualities. These materials provide mechanical support and possess bioactive components that promote wound healing, such as anti-inflammatory, antimicrobial, and antioxidant properties. Boswellia resin from Boswellia serrata, PVP, and PCL was obtained, and nanofibers were electrospinning to form them. The formulated nanofibers were further evaluated for entrapment efficiency, swelling index and moisture content. The in-vitro study showed formulation NF3 has the highest drug release. scanning electron microscopy (SEM) studies revealed a uniform surface of nanofiber mat.