Abstract
Dermatopathia pigmentosa reticularis (DPR) is a reticulate pigmentary disorder of as yet unclear inheritance that was first described in 1958. Since then only an additional eight cases have been reported, all in the European literature. To our knowledge, this is the first case from the United States of America and the first with an ultrastructural study.The patient is a 44-year-old man of mixed Black, Hispanic and American Indian descent with generalized, variably pigmented skin over the entire body present since birth.A punch biopsy of pigmented forearm skin was taken for light microscopy which demonstrated hyperkeratosis, an intact granular layer, and epidermal atrophy with focal liquefaction degeneration of the basal cell layer. The dermis showed pigment incontinence. Direct immunofluorescence was negative for immunoglobulins and complement at the basement membrane zone. A second skin biopsy of an elbow plaque showed the above changes except for the alteration of the basal layer.
Published Version
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