Abstract
The incorporation of [ 14C]linoleic acid, stearic acid and palmitic acid in the lipids of slices from biopsy samples of human muscle in four cases of progressive muscular dystrophy was studied by incubation of the tissue over 40 min and compared with normal muscle and adipose tissue. 1. 1. The influx of fatty acids is different in the three tissues. Considering the different specific activities of fatty acids there are comparable conditions for the lipid synthesis m all three tissues. 2. 2. The highest incorporation of fatty acids of the tissues studied was found in muscle. In adipose tissue the turnover averaged thirty times lower. The incorporation in muscular dystrophy hardly comes up to the values of normal muscle. 3. 3. The incorporation of linoleic acid and palmitic acid in sphingomyelin is decreased in dystrophic muscle, also the incorporation of linoleic acid in triglycerides is diminished. Palmitic acid incorporation was enlarged in muscular dystrophy. 4. 4. The incorporation of linoleic acid in phosphatidylcholine of dystrophic muscle is decreased. Therefore the relation of lysophosphatidylcholine/phosphatidylcholine is nearly one. The results were interpreted as signs of defective incorporation of linoleic acid in progressive muscular dystrophy.
Published Version
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