Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure.

Michael B Hennessy,Jing Jiang,John P Capitanio,Brenda Mccowan

doi:10.3389/fnbeh.2014.00309

Abstract

Social isolation is a major risk factor for the development of depressive illness; yet, no practical nonhuman primate model is available for studying processes involved in this effect. In a first study, we noted that adult male rhesus monkeys housed individually indoors occasionally exhibited a hunched, depressive-like posture. Therefore, Study 2 investigated the occurrence of a hunched posture by adult males brought from outdoor social groups to indoor individual housing. We also scored two other behaviors—lying on the substrate and day time sleeping—that convey an impression of depression. During the first week of observation following individual housing, 18 of 26 adult males exhibited the hunched posture and 21 of 26 displayed at least one depressive-like behavior. Over 2 weeks, 23 of 26 males showed depressive-like behavior during a total of only 20 min observation. Further, the behavior during the first week was positively related to the level of initial response to a maternal separation procedure experienced in infancy. In Study 3, more than half of 23 adult males of a new sample displayed depressive-like behavior during 10 min of observation each of Weeks 7–14 of individual housing. The surprisingly high frequency of depressive-like behavior in Studies 2 and 3 may have been due to recording behavior via camera with no human in the room to elicit competing responses. These results suggest that a common animal husbandry procedure might provide a practical means for examining effects of social isolation on depression-related endpoints in a nonhuman primate. The findings also suggest that trait-like differences in emotional responsiveness during separation in infancy may predict differences in responsiveness during social isolation in adulthood.

Highlights

Social isolation and loneliness are risk factors for developing depressive illness (Barnett and Gotlib, 1988; Bruce and Hoff, 1994; Cacioppo et al, 2010) though vulnerability varies widely across individuals (Wu et al, 2013)
Attempts to model the impact of social isolation on depression in laboratory animals date back to studies of Harlow and others examining the effects of prolonged maternal separation or isolation rearing in nonhuman primates (Kaufman and Rosenblum, 1967; Novak and Harlow, 1975; Mineka and Suomi, 1978)
In Studies 2 and 3 of the current report, we examine the relation of the Emotionality and Activity factor scores for Days 1 and 2 of the biobehavioral assessment (BBA) to the depressive-like response of these animals during social isolation in adulthood

Summary

Introduction

Social isolation and loneliness are risk factors for developing depressive illness (Barnett and Gotlib, 1988; Bruce and Hoff, 1994; Cacioppo et al, 2010) though vulnerability varies widely across individuals (Wu et al, 2013). Attempts to model the impact of social isolation on depression in laboratory animals date back to studies of Harlow and others examining the effects of prolonged maternal separation or isolation rearing in nonhuman primates (Kaufman and Rosenblum, 1967; Novak and Harlow, 1975; Mineka and Suomi, 1978). These approaches, uncommon, have been largely replaced by rodent studies of behavioral and biological consequences of social isolation that may be homologous to the depressogenic effects observed in humans. A several-hour period of isolation from the mother elicits a constellation of passive responses, including a hunched or crouched posture, eye-closure, and Frontiers in Behavioral Neuroscience www.frontiersin.org

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