Abstract
The Many Faces of Stress: Implications for Neuropsychiatric Disorders.
Highlights
When the stress response is efficient, it can induce adaptive neuroplasticity and improve cognition; when the stress response is overused, it can have toxic effects
A maladaptive stress response can lead to epigenetic changes associated with impaired brain functions and may trigger the development of neuropsychiatric disorders
The identification of neural mechanisms underlying resilience and vulnerability to stress is of crucial importance in understanding the pathophysiology of neuropsychiatric disorders and in developing improved treatments
Summary
When the stress response is efficient, it can induce adaptive neuroplasticity and improve cognition; when the stress response is overused, it can have toxic effects. Environmental stress is widely recognized as one of the main risk factors in neuropsychiatric diseases, including mood and anxiety disorders. A maladaptive stress response can lead to epigenetic changes associated with impaired brain functions and may trigger the development of neuropsychiatric disorders. Four papers within the special issue deal with the longterm impact of early-life stress on neurotransmission, behavior, and coping strategies in the adulthood.
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