Abstract
Cancer Triple-negative breast cancer (TNBC) is difficult to treat. Daniels et al. identified a metabolic vulnerability in TNBC patient cells and cell lines that may create a therapeutic opportunity for patients. The authors searched for metabolism-perturbing small-molecule compounds that sensitized TNBC lines to apoptosis induced by BH3 mimetics that block anti-apoptotic proteins. They found that inhibition of the rate-limiting enzyme of the nicotinamide adenine dinucleotide salvage pathway, specifically the loss of adenine downstream of inhibition, primed TNBC cells for apoptotic death. Sci. Signal. 14 , eabc7405 (2021).
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