Abstract
A stable nuclear ribosome system was obtained from isolated calf-thymus nuclei in which the incorporation of labeled amino acids into trichloroacetic acid-insoluble proteins is stimulated by the addition of DNA. It was suggested that the amino acid composition of the labeled products reflects the base composition of the DNA added and that an adenine-containing triplet in the DNA strand codes for lysine and a thymine-containing triplet for phenylalanine. Double-stranded DNA has less stimulatory activity than single-stranded DNA. No concomitant RNA synthesis takes place during DNA stimulation. The results obtained here may suggest that genetic information from DNA is directly transferred to the products in the nuclear ribosome system without any mediation through mRNA.
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