Abstract
Abstract Comparisons of the response of monkey and guinea pig ileum and human appendix to histamine, bradykinin, serotonin, and SRS-A (slow-reacting substance) are reported. The monkey and guinea pig ileum reacted equally to both histamine and bradykinin. The guinea pig ileum showed a greater response to serotonin than did the other tissues. On the other hand, the monkey ileum reacted more strongly to SRS-A substance than did the guinea pig ileum. The human appendix responded well to both histamine and bradykinin but gave only weak contractions with serotonin. The monkey ileum and human appendix were able to be passively sensitized in vitro by much less serum of allergic patients than was required to sensitize the guinea pig ileum. This sensitization of the guinea pig ileum was not destroyed when the atopic serum was heated at 56° C. for 4 hours. However, this same treatment of serum prevented sensitization of the monkey ileum and human appendix. In vitro sensitization was enhanced 2 to 10 times when serum was diluted in isotonic buffered glucose rather than Tyrode's solution, and also if succinic or maleic acids were added with the antigen for challenge.
Published Version
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