Abstract
The intestinal wall of the guinea-pig's ileum contains a histamine and pilocarpine antagonizing principle which can be washed out by repeated change of the suspending fluid (Tyrode's solution). The same antagonizing substance is formed anew, when the ileum is abandoned for 30 min in an aerated Tyrode's solution at 37° C. It can also be obtained in a more potent form, by incubating a whole small intestine in a test tube with Tyrode's solution, at 37° (“intestinal extract”) for half an hour. The substance also passes from the surface of an intact bowel into the peritoneal cavity, previously filled with Tyrode's solution. After a 30 min contact, the liquid aspirated from the peritoneal cavity shows a very intense histamine and pilocarpine inhibiting activity. Similar substances as found in the guinea-pigs ileum are also produced by the intestines of rats and rabbits.
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