Abstract
Plants continue to be a major source of medicines, as they have been throughout human history. In the present days, drug discovery from plants involves a multidisciplinary approach combining ethnobotanical, phytochemical and biological techniques to provide us new chemical compounds (lead molecules) for the development of drugs against various pharmacological targets, including cancer, diabetes and its secondary complications. In view of this need in current drug discovery from medicinal plants, here we describe another web database containing the information of pharmacophore analysis of active principles possessing antidiabetic, antimicrobial, anticancerous and antioxidant properties from medicinal plants. The database provides the botanical, taxonomic classification, biochemical as well as pharmacological properties of medicinal plants. Data on antidiabetic, antimicrobial, anti oxidative, anti tumor and anti inflammatory compounds, and their physicochemical properties, SMILES Notation, Lipinski's properties are included in our database. One of the proposed features in the database is the predicted ADMET values and the interaction of bioactive compounds to the target protein. The database alphabetically lists the compound name and also provides tabs separating for anti microbial, antitumor, antidiabetic, and antioxidative compounds. http://www.hccbif.info /
Highlights
Plants form the main ingredients of medicines in traditional systems of healing and have been the source of inspiration for several major pharmaceutical drugs
The use of plants as medicines has involved the isolation of active compounds, beginning with the isolation of morphine from opium in the early 19th century [1] and subsequently led to the isolation of early drugs such as cocaine, codeine, digitoxin and quinine, of which some are still in use [2, 3]
There is an increasing demand to identify and analyze the target proteins with their active sites and potential drug molecules that can bind to these sites .Many databases are available today to describe the medicinal plants and compounds [4, 5, 6]
Summary
Plants form the main ingredients of medicines in traditional systems of healing and have been the source of inspiration for several major pharmaceutical drugs. Isolation and characterization of pharmacologically active compounds from medicinal plants continue today. There is an increasing demand to identify and analyze the target proteins with their active sites and potential drug molecules that can bind to these sites .Many databases are available today to describe the medicinal plants and compounds [4, 5, 6]. Our focus is to provide the complete pharmacophore analysis of active principles possessing antidiabetic, antimicrobial, anticancerous and antioxidant properties from medicinal plants and the interaction of the compounds with their target proteins. As an additional effort to decipher research into technology this data base is created to document the complete research literatures about the medicinal compounds and the active site of their target proteins available and docked results of the compounds and their target proteins
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