Abstract
Background: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods : The roots and stem barks of plant were extracted using maceration method with n -hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results : The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n -hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n -hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions : This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
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