Hepatoprotective effect of the Hexane extract of Luffa echinata root and Stem bark against Tetrachloromethane Induced Hepatic Disorder in rats

Abstract

In many nations, long term liver syndromes are the principal cause of casualty. Medicinal drug obtained from fauna and floras are well-thought-out and valuable in the treatment of chronic diseases that require long-term treatment. An experiment was conducted to determine the potential outcome of a hexane extract of the root and stem bark of Luffa echinata (L.echinata) Roxb on tetra chloromethane (TCM) induced liver toxicity in female albino rats. The root and stem bark of L. echinata were treated with hexane (C6H6), and exposed to preliminary secondary metabolite screening for the presence of various therapeutic component. Tetra chloromethane has been used to cause the hepatic disease in albino rats, which was subsequently treated with Hexane extract. Biochemical markers including entire bilirubin (BR), serum glutamic–oxaloacetic transaminase (SGOT) enzyme, serum glutamic –pyruvic transaminase (SGPT) enzyme, and total serum protein (TSP) in blood serum were used to assess the patient. The synergistic outcome of root and stem bark hexane extract on the damage liver tissues were also investigated histopathologically. According to the findings, Hexane extract has a strong hepatoprotective effect.