Cytotoxic and anticancer activity of mixed metal oxide FeO: MnO nanostructures

Abstract

Cancer is one of the most difficult diseases to treat because of its potential to evolve into a more complicated multidimensional structure over time and spread uncontrollably. Therefore, humanity has yet to fully grasp all aspects of the disease. As a consequence, the development of novel, more effective, and non-hazardous treatments in this field is expanding. As a result of better knowledge of the interaction of nanomaterials with cells, nanobiomaterials have attracted a great deal of interest from researchers in cancer therapy. The biomedical properties of iron oxide nanoparticles provide significant studies on the potential, difficulties, and challenges of cancer nanomedicine. Mixed metal oxide nanoparticles have the ability to overcome all of these difficulties. In this study, mixed oxides of iron and manganese (FeO: MnO) nanostructure were successfully prepared by the chemical co precipitation method. Deoxyribonucleic acid (DNA), the most unique organic substance, is used as a biocompatible capping agent for the production of fine nanoparticles. Here, the characterization, cytotoxicity, and anticancer effects of the samples were investigated. The formation of mixed metal oxides of α-Fe2O3: Mn2O3 nanoparticles (NPs) was confirmed by Energy-dispersive X-ray spectroscopy (EDS), XRD analysis, Fourier transform infrared spectroscopy (FTIR) and Field emission Scanning Electron Microscope (FESEM) studies of the samples. Structural refinement of the sample is carried out using Rietveld refinement. The magnetic properties of the sample were measured using vibrating-sample magnetometer (VSM) studies. The cytotoxic effect (L929 cells) and anticancer activity (A549 cells) of the sample on the viability of cells were evaluated by direct observation of cells by an inverted phase contrast microscope and followed by the MTT assay method. The sample showed excellent biocompatibility and anticancer activity. This can be preferable for biomedical applications.