Abstract
AbstractCatalytic cyclization reactions and new stoichiometric skeletal rearrangement cycloisomerizations of 2‐ethynylphenyl vinyl ethers containing methyl substituents on the vinyl groups by using [Ru]Cl {[Ru]=Cp(PPh3)2Ru, Cp=η5‐cyclopentadienyl} were observed in MeOH and CH2Cl2, respectively. In MeOH, the catalytic cyclization of three different enynes gave the corresponding benzoxepine derivatives in high yields in each case. Interestingly, in the stoichiometric reactions of [Ru]Cl with enynes, two unprecedented rearrangements of enynes were observed in CH2Cl2. The presence of a methyl group in the vinyl unit plays a critical role in choosing one of the double bonds of the vinylidene ligand, that is, the Ru=Cα or the Cα=Cβ bond, for the [2+2] cycloaddition in the cycloisomerization processes. Structure determination by single‐crystal X‐ray diffraction analysis along with various isotope studies corroborated the proposed mechanisms.
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