Abstract
As a novel immune-active agent for cancer treatment, viruses havethe ability of infecting and replicating in tumor cells. The safety and efficacy of viruses hasbeen tested and confirmed in preclinical and clinical trials. In the last decade, virotherapy has been adopted as a monotherapy or combined therapy with immunotherapy, chemotherapy, or radiotherapy, showing promising outcomes against cancer. In this review, the current strategies of viruses used in clinical trials are classified and described. Besides this, the challenge and future prospectsof virotherapy in the management for cancer patients arediscussed in this review.
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