Abstract
Modern genetic engineering technologies, such as base editing (BE) and prime editing (PE), have proven to be effective and reliable genome editing tools that do not require the introduction of double-strand breaks in DNA and the presence of donor templates. Relatively new, they quickly gained recognition for their accuracy, simplicity and multiplexing capabilities. This review summarizes new literature on these technologies: architecture and methods for creating editors, specificity, efficiency and versatility. The advantages, disadvantages and prospects for using these editors in basic and applied research are discussed. The information presented in the review may be useful for planning genome editing studies and for analyzing their results when solving various problems in fundamental biology, biotechnology, medicine and agriculture.
Published Version
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