Curative effect of testosterone combined with solifenacin for patients with lower urinary tract symptoms in late-onset hypogonadism

Abstract

Objective To investigate the clinical efficacy and safety of testosterone supplement and M receptor blockers in the treatment of patients with lower urinary tract symptoms(LUTS) in late-onset hypogonadism(LOH). Methods 28 cases diagnosed as LOH with mild to moderate LUTS were collected.They were given testosterone supplementation (oral testosterone undecanoate capsules, 80mg, 2 times/d) and M receptor blocker (oral succinate solifenacin tablet, 5mg, 1 time/d) treatment for 1-3 months.After treatment for 1 month and 3 months respectively, reviewd PSA, serum total testosterone (TT), international prostate of urinary storage symptoms score (urinary storage IPSS), quality of life (QOL) score, international index of erectile function (IIEF-5) score, maximum urinary flow rate (Qmax), residual urine (Ru) and rectal examination (DRE). The improvement of LUTS before and after treatment was evaluated. Results 1 month after treatment, 1 patient was difficult to tolerate the solifenacin side effects and took testosterone supplementation alone.The rest 27 patients were able to take medicine for 3 months.After 1 month and 3 months treatment, the IPSS score had significant differences compared with before treatment[(10.3±2.1)points vs (14.2±3.3) points and (9.42±1.8) points vs (14.2±3.3) points, t=13.67, 14.72, all P<0.05]. After 3 months treatment, the QOL and IIEF-5 scores were (2.1±0.7) points vs (4.3±0.6) points and (16.8±3.6) points vs (11.9±2.5) points, Qmax was (12.5±5.6)mL/s vs (9.8±4.8)mL/s(t=6.42, 5.64, 14.92, all P<0.05), the difference was statistically significant compared with before treatment.There were no significant changes in PSA and RU before and after treatment.All patients had no severe complications such as acute urinary retention. Conclusion Combination of testosterone and testosterone in the treatment of LUTS patients in LOH is safe and effective, and can significantly improve the LUTS and quality of life. Key words: Late-onset hypogonadism; Lower urinary tract symptoms; Testosterone supplement; Solifenacin