Abstract
Objective To observe the curative effect of nicorandil on the elderly patients with multiple coronary branch lesions and chronic heart failure(CHF). Methods Ninety-two elderly patients with multiple coronary branch lesions and CHF were randomly divided into control group and the observation group, with 46 cases in each group. On the basis of the conventional treatment, the control group was treated with oral mononitrate and isosorbide mononitrate sustained release tablets of 40 mg, 1 time daily, and the observation group was given nicorandil for 5 mg daily, 3 times daily. Before and after the treatment, the values of plasma brain natriuretic peptide (BNP) were tested, at the same time echocardiographic was used to detect the left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), 6 min walking distance (6 MWDS). The clinical efficacy and adverse reactions of the two groups were observed after 4 weeks of treatment. Results The markedly effective and effective rates of angina after treatment in the observation group were significantly higher than those in the control group (32.6% vs. 10.9%, 87.0% vs. 58.7%, P<0.05). The markely effective and effective rates of cardiac function after treatment in the observation group were higher that those in the concrol group (34.8% vs. 15.2%, 83.0% vs. 57.0%, P<0.05) The plasma BNP levels and LVEDD were significantly lower, while the LVEF was significantly higher in observation group than those before treatment and those in the control group after 4 weeks of treatment(P<0.05). The 6-minute walking distance (6 MWD) was significantly longer in observation group than that before treatment and that in the control group after 4 weeks of treatment(P<0.05). Conclusions Nikodil can alleviate the symptoms of angina in the elderly patients with coronary artery disease and chronic heart failure, and can further improve cardiac function. Key words: Nicorandil; Coronary artery disease; Heart failure; Angina pectoris; Brain natriuretic peptide; Left ventricular ejection fractionleft
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
