Abstract
Background Cytotoxic T lymphocyte antigen CTLA the T cell surface antigen is expressed during activation Prostate cancer PCa is one of the most common cancers in Western population and its rate is increasing in the Eastern World The aim of this study was to evaluate cytotoxic T lymphocyte associated antigen CTLA gene A G polymorphisms in prostate cancer patients Material and methods This study included mean age plusmn years healthy controls and mean age plusmn years patients with prostate cancer The CTLA gene A G rs gene regions were amplified using polymerase chain reaction PCR detected by restriction fragment length polymorphism RFLP Results At the end of ourstudy it was foundthat the prevalence of genotypes of AA wild type AG heterozygous mutant and GG homozygous mutant profiles for the CTLA gene A G polymorphism were and respectively in prostate cancer patients and and respectively in healthy control groups Conclusion No association was found in terms of the CTLA gene A G polymorphism amongprostate cancer patients and the control groups in Turkish population
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