CtDNA for early cancer diagnosis in Pacific Communities

Abstract

Abstract Circulating tumour DNA (ctDNA) refers to small fragments of tumour DNA found in the blood circulation, recognised by the presence of mutations in cancer genes. These DNA fragments can be isolated and quantified to obtain data about the cancer’s size and progression. Since gaining access to and obtaining biopsy samples from solid cancers in people is not always possible, the possibility of utilizing a simple blood sample to allow detection and monitoring of cancer growth is highly desirable. It is anticipated this simple method of detecting and monitoring cancer will enhance the precision of cancer diagnostics and surveillance and also lead to improved cancer health outcomes for Pacific Peoples. The purpose of this work was to support engagement with Pacific communities and share, and discuss and explore current research efforts, that included the potential utilization of ctDNA to improve the diagnosis, care and health outcomes of Pacific Peoples. A Pacific Fono (gathering) was held in the Hutt Valley region to promote appropriate knowledge translation activity, engagement and meaningful dialogue between researchers and the Pacific communities regarding current research works and findings of direct relevance and significance to Pacific communities. The Pacific community response to this research outreach effort was overwhelmingly positive and encouraging. Discussions were respectful and informative with shared information being exchanged between researchers and those in attendance. Feedback included expressed support for regarding the ctDNA research and for other areas of research focus that would be of benefit to Pacific communities. Requests from Pacific community members were also made for future similar events to be held.