Year-end Sale % OFF 
Abstract
In the title compound, C22H24N4O4S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms. The 3-methoxyphenyl ring, at the chiral C atom opposite the other N atom, is positioned axially and is inclined to the thiazolopyrimidine ring with a dihedral angle of 83.88 (7)°. The thiazole ring is essentially planar (r.m.s. deviation = 0.0034 Å). In the crystal, pairs of weak C—H⋯O hydrogen bonds link molecules related by twofold rotation axes to form R 2 2(8) rings, which in turn are linked by weak C—H⋯N interactions, forming ribbons along [-110]. In addition, π–π stacking interactions [centroid—centroid distance = 3.5744 (15) Å] connect the ribbons, forming slabs lying parallel to (001).
Highlights
In the title compound, C22H24N4O4S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms
H O hydrogen bonds link molecules related by twofold rotation axes to form R22(8) rings, which in turn are linked by weak C—H N interactions, forming ribbons along [110]
The title compound, an intermediate, was isolated and we report on its crystal structure
Summary
C22H24N4O4S, the central pyrimidine ring adopts a sofa conformation with the ring-junction N atom displaced by 0.2358 (6) Å from the mean plane of the remaining ring atoms. H O hydrogen bonds link molecules related by twofold rotation axes to form R22(8) rings, which in turn are linked by weak C—H N interactions, forming ribbons along [110]. H-atom parameters constrained max = 0.49 e Å3 For background and pharmacological properties of pyrimidine and thiazolopyrimidine derivatives, see: Singh et al (2011); Ozair et al (2010a,b); Sayed et al (2010); Zhi et al (2008); Mobinikhaledi et al (2005).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Acta Crystallographica Section E Crystallographic Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
