Abstract
In the title compound, C24H22N2O4S, the central pyrimidine ring is significantly puckered, assuming a conformation intermediate between a boat and a screw boat. The nearly planar thiazole ring (r.m.s. deviation = 0.0258 Å) is fused with the pyriamidine ring, making a dihedral angle of 9.83 (7)°. The carboxyl group is in an extended conformation with an anti-periplanar orientation with respect to the dihydropyrimidine ring. The benzene ring linked at the chiral C atom is perpendicular to the pyrimidine ring [dihedral angle = 85.21 (8)°] whereas the phenyl ring is nearly coplanar, making a dihedral angle of 13.20 (8)°. An intramolecular C—H⋯S hydrogen bond is observed. The crystal packing is influenced by weak intermolecular C—H⋯π interactions and π–π stacking between the thiazole and phenyl rings [centroid–centroid distance = 3.9656 (10) Å], which stack the molecules along the c axis.
Highlights
In the title compound, C24H22N2O4S, the central pyrimidine ring is significantly puckered, assuming a conformation intermediate between a boat and a screw boat
The carboxyl group is in an extended conformation with an antiperiplanar orientation with respect to the dihydropyrimidine ring
The benzene ring linked at the chiral C atom is perpendicular to the pyrimidine ring [dihedral angle =
Summary
R factor = 0.043; wR factor = 0.113; data-to-parameter ratio = 21.9
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