Abstract
We have determined the promoter CpG island methylation status of O 6-methylguanine-DNA methyltransferase ( MGMT), glutathione-S-transferase P1 ( GSTP1) , death-associated protein kinase ( DAPK) , p14 ARF, thrombospondin-1 ( THBS1) , tissue inhibitor of metalloproteinase-3 gene ( TIMP-3) , p73, p16 INK4A, RB1, and TP53 genes in three primary central nervous system lymphomas (PCNSL). Five genes ( GSTP1, DAPK, TIMP-3, p16 INK4A, and RB1) were hypermethylated in two samples, whereas MGMT, THBS1, and p73 were aberrantly methylated in only one sample. No case presented CpG island methylation for the p14 ARF and TP53 genes. These findings concur with previous data suggesting a frequent inactivation of p16 INK4A and very limited involvement of TP53 in PCNSL and also provide insights into the epigenetic molecular involvement of other tumor-related genes in this neoplasm.
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