COVID-19 и хроническая гастроэнтерологическая патология: особенности течения, тактика ведения, исходы

Abstract

National and international clinical guidelines provide detailed information on the diagnosis and treatment of COVID-19 infection, but long-term damage to multiple organs and systems associated with the disease, especially in patients with aggravated premorbid history, is still barely understood. The digestive system appears to be a sensitive target for SARS-CoV-2, and there is evidence of long-term persistence of the virus in the gastrointestinal (GI) tract without its detection in the respiratory system. A quarter to half of COVID-19 patients have GI symptoms, which are associated with a more severe disease course. The virus can affect any part of the digestive system, and people with underlying GI diseases are at greatest risk for adverse outcomes. The probability of having a post-infectious pathology is evident, but of practical interest is the impact of current or past COVID-19 infection on the course of gastrointestinal pathology. Some patients with chronic GI diseases are more likely to develop COVID-19 disease. In these patients, it is difficult to diagnose the infectious process, and there is a risk of a more severe course and adverse outcomes of COVID-19. In this regard, the management of comorbid patients requires certain adjustments to standard treatment regimens for novel coronavirus infection. Key words: COVID-19, gastrointestinal pathology, children, post-COVID syndrome