КЛИНИЧЕСКИЕ И ПРОГНОСТИЧЕСКИЕ КРИТЕРИИ ОСЛОЖНЕННОГО ТЕЧЕНИЯ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ (COVID-19)

Abstract

Relevance. The pandemic of new coronavirus infection COVID-19 is the main topic and problem of modern medicine associated with the necessity of rapid diagnostics and medical care rendered to such patients Nowadays, individual pathogenetic mechanisms of infection COVID-19 are determined, however, clinical and epidemiological particularities of the disease are being intensively investigated, and new agents for prevention and treatment of infection COVID-19 are being developed. The determination of predictors of the severe disease course and exposure methods is definitely important. The studies have shown that the presence of various concurrent comorbid diseases in patients hospitalized with COVID-19 negatively affects the disease course and its prognosis. Study objective: the analysis of the observation results and clinical outcomes of clinical course (clinical masks) of new coronavirus infection COVID-19 with the distribution by age, gender and incidence of somatic diseases, identification of the pattern of visceral organ damages in coronavirus infection caused by virus SARS-CoV-2. Materials and methods: 110 patients with virus pneumonia caused by COVID-19 were enrolled to the study. The presence of risk factors of the severe disease course variants and intensity of the somatic disorder in necropsy of patients died were evaluated. Study results: The found analysis data suggest that the most significant predictors of the severe course of COVID-19 are arterial hypertension with a high and very high cardiovascular risk, followed by a renal disorder, type 2 diabetes mellitus, obesity, hepatic and heart failure. Conclusion. The found analysis data suggest that the most significant predictors of the severe course of COVID-19 are arterial hypertension with a high and very high cardiovascular risk, followed by a renal disorder, type 2 diabetes mellitus, obesity, hepatic and heart failure.