Abstract
The cover picture depicts an efficient synthetic strategy devising selective deprotection of N2‐Cbz from N1,N2‐diCbz piperazic acid‐containing peptides to achieve a concise synthesis of piperazic acid‐containing cyclodepsipeptide core of verucopeptin with an overall yield of 21%, with the key steps of late stage coupling of piperazic acid with 3‐hydroxyleucine derivatives, and HATU‐mediated macrolactamization of 19‐membered macrocycle at N9 and C10. More details are discussed in the article by Long et al. on page 2077—2081.image
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