Abstract
Background: Stroke is the second leading cause of death in the world, causing thousands of hospital admissions and whose morbidity and health care costs are high. Objectives: To analyze the temporal behavior of hospitalization of elderly people due to stroke in Brazil, regions and Federation Units (UF), 2008- 2019. Design and setting: Ecological study. The space units were Brazil, its regions and Federation Units. Methods: Data were collected on the DATASUS online platform: number of admissions, number of Hospitalization Authorizations approved (AIH), total AIH value (R$), average AIH value (R$), and average value hospitalizations (R$). Was used the joinpoint regression model to calculate the Annual Percentage Change (APC) and the Average Annual Percent Change (AAPC) with 95% confidence interval and a 5% significance level. Results: Approximately 1.4 million hospitalizations were identified in Brazil, with a total cost of R$ 1.6 billion reais and an average of 1.1 thousand reais. The Southeast region stood out in the number of hospitalizations (n = 574399; 42.1%), approved AIH (n = 574625; 42.1%) and total amount (R $ 677,444,257.54; 43.4%). Throughout the time series, the number of hospitalizations increased by 52.3% and the number of approved AIH increased by 52.4%. The mean values of hospitalizations and AIH increased, respectively, 55.4% (AAPC: 3.9; CI: 3.2; 4.5) and 55.3% (AAPC: 3.9; CI: 3, 2; 4.5), while the total value of hospitalizations increased by 134.9% (AAPC 8.0; CI: 6.9; 9.1). Conclusions: There was an increase in variables related to hospitalization and stroke costs in the elderly in Brazil.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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