Abstract
BackgroundThe prevalence of antimicrobial resistance among gram-negative pathogens in complicated intra-abdominal infections (cIAIs) has increased. In the absence of timely information on the infecting pathogens and their susceptibilities, local or regional epidemiology may guide initial empirical therapy and reduce treatment failure, length of stay and mortality. The objective of this study was to assess the cost-effectiveness of ceftolozane/tazobactam + metronidazole compared with piperacillin/tazobactam in the treatment of hospitalized US patients with cIAI at risk of infection with resistant pathogens.MethodsWe used a decision-analytic Monte Carlo simulation model to compare the costs and quality-adjusted life years (QALYs) of persons infected with nosocomial gram-negative cIAI treated empirically with either ceftolozane/tazobactam + metronidazole or piperacillin/tazobactam. Pathogen isolates were randomly drawn from the Program to Assess Ceftolozane/Tazobactam Susceptibility (PACTS) database, a surveillance database of non-duplicate bacterial isolates collected from patients with cIAIs in medical centers in the USA from 2011 to 2013. Susceptibility to initial therapy was based on the measured susceptibilities reported in the PACTS database determined using standard broth micro-dilution methods as described by the Clinical and Laboratory Standards Institute (CLSI).ResultsOur model results, with baseline resistance levels from the PACTS database, indicated that ceftolozane/tazobactam + metronidazole dominated piperacillin/tazobactam, with lower costs ($44,226/patient vs. $44,811/patient respectively) and higher QALYs (12.85/patient vs. 12.70/patient, respectively). Ceftolozane/tazobactam + metronidazole remained the dominant choice in one-way and probabilistic sensitivity analyses.ConclusionsBased on surveillance data, ceftolozane/tazobactam is more likely to be an appropriate empiric therapy for cIAI in the US. Results from a decision-analytic simulation model indicate that use of ceftolozane/tazobactam + metronidazole would result in cost savings and improves QALYs, compared with piperacillin/tazobactam.
Highlights
The prevalence of antimicrobial resistance among gram-negative pathogens in complicated intra-abdominal infections has increased
Results from a decision-analytic simulation model indicate that use of ceftolozane/ tazobactam + metronidazole would result in cost savings and improves quality-adjusted life years (QALYs), compared with piperacillin/tazobactam
Under the base case scenario, ceftolozane/tazobactam + metronidazole arm resulted in lower total costs than the piperacillin/tazobactam arm ($44,226 per patient vs. $44,811)
Summary
The prevalence of antimicrobial resistance among gram-negative pathogens in complicated intra-abdominal infections (cIAIs) has increased. In the absence of timely information on the infecting pathogens and their susceptibilities, local or regional epidemiology may guide initial empirical therapy and reduce treatment failure, length of stay and mortality. The objective of this study was to assess the cost-effectiveness of ceftolozane/tazobactam + metronidazole compared with piperacillin/tazobactam in the treatment of hospitalized US patients with cIAI at risk of infection with resistant pathogens. Intra-abdominal infections (IAIs) represent a wide variety of pathological conditions caused by inflammation or perforation of the intra-abdominal organs. In the latter case, complicated IAIs (cIAIs) arise causing localized or diffuse peritonitis [1]. If the initial empiric therapy chosen has in vitro activity against the pathogen isolated it is termed initial appropriate antibiotic therapy (IAAT), whereas one without in vitro activity is termed initial inappropriate empiric therapy (IIAT)
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