Cortical Abnormalities in Creutzfeldt-Jakob Disease Measured by MEG, a Case Report

Abstract

Event Abstract Back to Event Cortical Abnormalities in Creutzfeldt-Jakob Disease Measured by MEG, a Case Report Eero Pekkonen1*, Juha Wilenius2, Jukka Lyytinen1, Anders Paetau3, Maarit Palomäki4 and Jyrki Mäkelä5 1 University of Helsinki, Department of Neurology, Finland 2 University of Helsinki, BioMag laboratory, Finland 3 University of Helsinki, Department of Pathology, Finland 4 University of Helsinki, Department of Radiology, Finland 5 Helsinki University Central Hospital, BioMag laboratory, Finland Creutzfeldt-Jakob Disease (CJD) is a rare neurodegenerative disease, which belongs to a group of spongiform encephalopathies termed prion diseases.Main symptoms of CJD are progressive dementia, py-ramidal and extrapyramidal symptoms, and myoclonus. Currently there is no effective therapy for CJD. Definite diagnosis is based on autopsy findings.Here we report a male patient with a rapidly progres-sive memory disorder, ataxia and myoclonus. EEG showed slow wave activity, and head MRI revealed in-creased basal ganglia and left-dominant increase in cor-tical signal intensity. In cerebrospinal fluid (CSF) 14-3-3 test was positive. The autopsy confirmed the sporadic CJD.A 306-channel MEG measurement was performed to the patient. Spontaneous brain activity and auditory evoked fields (AEF) were recorded.Both hemispheres had slow wave activity and periodic sharp waves, activity being more pronounced in the left, more damaged, hemisphere. The source of auditory N100m were more lateral in the left than in the right hemisphere. P200m was larger and more posterior in the left hemisphere compared with the right hemisphere. This is the first MEG-recording of a patient with spo-radic CJD. The more damaged left hemisphere in MRI had more pronounced slow and sharp waves in MEG. The sources of auditory responses and amplitude of later 200m deflection were different between the more and less damaged hemispheres. MEG appears to be suitable to investigate and locate brain activity in prion diseases. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG: Clinical applications Citation: Pekkonen E, Wilenius J, Lyytinen J, Paetau A, Palomäki M and Mäkelä J (2010). Cortical Abnormalities in Creutzfeldt-Jakob Disease Measured by MEG, a Case Report. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00286 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Apr 2010; Published Online: 05 Apr 2010. * Correspondence: Eero Pekkonen, University of Helsinki, Department of Neurology, Helsinki, Finland, eero_pekkonen@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Eero Pekkonen Juha Wilenius Jukka Lyytinen Anders Paetau Maarit Palomäki Jyrki Mäkelä Google Eero Pekkonen Juha Wilenius Jukka Lyytinen Anders Paetau Maarit Palomäki Jyrki Mäkelä Google Scholar Eero Pekkonen Juha Wilenius Jukka Lyytinen Anders Paetau Maarit Palomäki Jyrki Mäkelä PubMed Eero Pekkonen Juha Wilenius Jukka Lyytinen Anders Paetau Maarit Palomäki Jyrki Mäkelä Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.