Alterations in auditory evoked magnetic fields in newborns exposed to buprenorphine during pregnancy

Abstract

Event Abstract Back to Event Alterations in auditory evoked magnetic fields in newborns exposed to buprenorphine during pregnancy Päivi Nevalainen1*, Kaisa Kivistö2, Leena Lauronen3, Satu Kivitie-Kallio2, Sarimari Tupola2 and Elina Pihko4 1 Helsinki University Central Hospital, BioMag laboratory, Finland 2 Hospital for Children and Adolescents, Department of Social Pediatrics, Finland 3 Helsinki University Central Hospital, Department of Clinical Neurophysiology, Hospital for Children and Adolescents, Finland 4 Helsinki University of Technology, Low Temperature Laboratory, Finland Neonatal abstinence syndrome (NAS) of opiate-exposed newborns is characterized by symptoms of central nervous system (CNS) hyperirritability. The specific effects NAS has on neuronal function are poorly characterized by modern neurophysiological methods. We recorded auditory (AEFs) and somatosensory evoked magnetic fields (SEFs) in order to evaluate whether NAS in neonates causes changes in neuronal function of the auditory or somatosensory system. Data was obtained from 11 infants (8 males and 3 females) exposed to buprenorphine during pregnancy, and in 13 healthy fullterm infants. The tactile and auditory stimuli were given in turn in one recording session. The interstimulus interval (ISI; onset-to-onset) for each stimulus type was 2 s. Consequently the ISI between an auditory and tactile stimulus was 1 s. The tactile stimulus was a tap on the volar side of the right index finger and the auditory stimuli were utterances of separated, long vowels [a:] delivered to the right ear. MEG was recorded from the contralateral (left) hemisphere. The SEF consisted of two components at around 60 (M60) and 200 ms (M200) without any significant differences between patients and controls. The AEF was a wide deflection with two peaks at around 250 (M250) and 600 ms (M600). Equivalent current dipoles (ECDs) underlying both responses, particularly the latter, were significantly stronger in the patients than controls. The enhanced AEFs in contrast with normal SEFs suggest different effects of buprenorphine on the two sensory systems. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Fetal and neonatal biomagnetism Citation: Nevalainen P, Kivistö K, Lauronen L, Kivitie-Kallio S, Tupola S and Pihko E (2010). Alterations in auditory evoked magnetic fields in newborns exposed to buprenorphine during pregnancy. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00140 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Mar 2010; Published Online: 25 Mar 2010. * Correspondence: Päivi Nevalainen, Helsinki University Central Hospital, BioMag laboratory, Helsinki, Finland, paivi.nevalainen@hus.fi Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Päivi Nevalainen Kaisa Kivistö Leena Lauronen Satu Kivitie-Kallio Sarimari Tupola Elina Pihko Google Päivi Nevalainen Kaisa Kivistö Leena Lauronen Satu Kivitie-Kallio Sarimari Tupola Elina Pihko Google Scholar Päivi Nevalainen Kaisa Kivistö Leena Lauronen Satu Kivitie-Kallio Sarimari Tupola Elina Pihko PubMed Päivi Nevalainen Kaisa Kivistö Leena Lauronen Satu Kivitie-Kallio Sarimari Tupola Elina Pihko Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.