MEG of Parkinsonian patients with deep brain stimulation

Abstract

Event Abstract Back to Event MEG of Parkinsonian patients with deep brain stimulation Katja Airaksinen1, 2*, Jyrki P. Mäkelä1, Samu Taulu3, Antti Ahonen3, Juha Pohjola4, Jussi Nurminen1, Alfons Schnitzler5, 6 and Eero Pekkonen2 1 Helsinki University Central Hospital, BioMag laboratory, Finland 2 Helsinki University Central Hospital, Department of Neurology, Finland 3 Elekta Neuromag, Finland 4 Helsinki University Central Hospital, Department of Neurosurgery, Finland 5 Heinrich-Heine-University, Department of Neurology, Germany 6 Heinrich-Heine-Univeristy, Institute of Clinical Neuroscience and Medical Psychology, Germany Our aim was to clarify the mechanism of action of deep brain stimulation (DBS) of subthalamic nucleus (STN) in patients with Parkinson's disease (PD). We studied 12 advanced PD patients with STN DBS using a 306-channel MEG-system (Elekta Neuromag®) both when the stimulator was on and off. Auditory evoked fields (AEFs) were elicited by 1-kHz tones delivered to each ear separately and somatosensory evoked fields (SEFs) by electrical pulses delivered to the median nerve at both wrists. Spontaneous MEG was recorded in combination with EMG from extended arm of one patient before and after DBS implantation. The magnetic artifacts caused by DBS were suppressed by the spatiotemporal signal space separation (tSSS) -method. Single dipole models for AEFs and SEFs were constructed. The source strengths of AEF N100m and SEF P60m were calculated both with DBS on and off. Coherence spectra between MEG signals and wrist extensor EMG were studied when DBS was on and off both before and after operation. DBS significantly enhanced AEF N100m to ipsilateral stimulation in the right hemisphere (49 ± 17 nAm DBS on, 43 ± 16 nAm DBS off, p=0.02). The mean source strengths of contralateral N100m also increased when DBS was on (n.s.). The mean SEF source strengths of P60m were stronger when stimulator was on than off (n.s.). In one patient the MEG-EMG coherence was abolished 0.5 months after DBS implantation. Four months after implantation the coherence reappeared when DBS was off, whereas it was suppressed when DBS was on. DBS significantly diminished motor symptoms in the patients. MEG with tSSS allows to study DBS effects in PD. DBS appears to modulate auditory processing in PD patients, and have a modest effect on SEFs. Data of one patient suggests that DBS suppresses the MEG-EMG coherence. In line with data from animal models, DBS modulates cortical functions of the human brain. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: MEG: Clinical applications Citation: Airaksinen K, Mäkelä JP, Taulu S, Ahonen A, Pohjola J, Nurminen J, Schnitzler A and Pekkonen E (2010). MEG of Parkinsonian patients with deep brain stimulation. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00285 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Apr 2010; Published Online: 05 Apr 2010. * Correspondence: Katja Airaksinen, Helsinki University Central Hospital, BioMag laboratory, Helsinki, Finland, katja.airaksinen@helsinki.fi Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Katja Airaksinen Jyrki P Mäkelä Samu Taulu Antti Ahonen Juha Pohjola Jussi Nurminen Alfons Schnitzler Eero Pekkonen Google Katja Airaksinen Jyrki P Mäkelä Samu Taulu Antti Ahonen Juha Pohjola Jussi Nurminen Alfons Schnitzler Eero Pekkonen Google Scholar Katja Airaksinen Jyrki P Mäkelä Samu Taulu Antti Ahonen Juha Pohjola Jussi Nurminen Alfons Schnitzler Eero Pekkonen PubMed Katja Airaksinen Jyrki P Mäkelä Samu Taulu Antti Ahonen Juha Pohjola Jussi Nurminen Alfons Schnitzler Eero Pekkonen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.