Abstract
Objective To investigate the correlations of lymphatic vessel density (LVD)and clinicopathologic parameters in gastric carcinoma. Methods The expression of monoclonal antibody D2-40 was detected by immunohistochemistry and to count LVD in gastric carcinoma. Results LVD mean was 18.19.7 in 52 cases of gastric carcinoma. 19. 9010. 13 and 16. 449.62 in the peritumoural and intratumoural area,respectively, were significantly higher than 6.583.87 in normal gastric tissue (P＜0.05 ).23.211.6 of poorly-differentiated was significantly higher than 15.75.9 of differentiated in peritumoural area( P＜0.05 ). 21. 910. 8 in lymphatic metastasis was obviously higher than 14.95.9 in non-metastasis( P＜0.05). LVD of edges in gastric carcinoma was not related with invasion depth and clinical stage(P＞0.05 ). There no was significant difference between LVD in peritumoral and intratumoural areas (P＞0.05). Conclusion LVD in the peritumoural and intratumoural area were significantly higher than in normal gastric tissue, and closely associated with differentiation degree and mestasis. It is suggest that LVD increasing may be concerned with metastasis in gastric carcinoma. Key words: Stomach neoplasm; D2-40; Lymphatic vessel density; Metastasis
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