Correlations of estradiol and testosterone in hyperuricemia patients

Abstract

Objective To evaluate the serum concentrations of estradiol and testosterone in hyperuricemia patients and possible correlations of the two factors and uric acid (UA) in hyperuricemia (HUA) patients. Methods This was a case control study.We involved 90 hyperuricemia patients,103 healthy controls.Estradiol,testosterone,UA,serum glucose,lipid profile,creatinine and body mass index (BMI) were estimated in two groups.The statistical analysis of the data were performed using SPSS version 19.0 software.The estradiol,testosterone,UA,serum glucose,lipid profile,serum creatinine and BMI levels between the two groups were compared using the Student′s t-test.Pearson correlation test was used to assess the correlation between serum UA levels and these indexes. Results Serum levels of estradiol in healthy subjects and hyperuricemia patients were 82.2 (55.6-108.8) pmol/L,65.8 (36.6-95.0) pmol/L respectively; the serum levels of UA were 300.8 (207.2-394.4) μmol/L,426.9 (370.1-483.7) μmol/L,respectively.The levels of estradiol were higher in the healthy control group than those in the hyperuricemia group.There were significant differences of estradiol levels between these two groups (P<0.05).Estradiol was negatively correlated with UA (r=-0.319,P<0.01),so was testosterone (r=-0.312,P<0.01). Conclusion The findings of the present study suggest that in hyperuricemia patients,there are associations between estradiol and UA and the levels of serum estradiol might be used as biomarkers in hyperuricemia.(Chin J Lab Med,2013,36:1131-1133) Key words: Hyperuricemia; Estradiol; Testosterone