Clinical features of hyperuricemia and relationship between serum uric acid and metabolic syndrome in health examination of population

Abstract

Objective To evaluate the clinical features of hyperuricemia (HUA) and relationship between serum uric acid (SUA) and metabolic syndrome (MS) in adults.Methods Data were gathered from medical examination among adults age ≥ 20 years,and totally 18 862 subjects were analyzed in this study.Results The prevalence of HUA was 14.8％ (2788/18 862).The rate was 18.4％( 1926/10 445) in men,10.2％ (862/8417) in women.The prevalence of HUA was increased with age,there was significant difference among different age (P =0.000),the rate in men was higher than that in women (P ＜ 0.01 or ＜0.05 ).Compared with normal SUA Patients,the levels of body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),total cholesterol (TC),triacylglycerol (TG) and lowdensity lipid cholesterol (LDL-C) were markedly elevated (P ＜0.01 or ＜0.05),and the level of highdensity lipid cholesterol (HDL-C) was markedly decreased in HUA patients (P ＜0.05).Stepwise regression analysis showed that BMI,SBP,DBP,fasting plasma glucose (FPG),TG,HDL-C were the independent correlation factor of SUA.The incidence of hypertension,over weight/obesity,dyslipidosis,hyperglycosemia and MS in HUA patients [24.1％ (672/2788),36.2％ (1009/2788),31.2％ (870/2788),18.0％ (502/2788),20.8％(580/2788) ] was significantly higher than that in normal SUA patients [ 18.2％ (2925/16 074),26.4％(4244/16 074),22.0％(3536/16 074),15.00(2411/16 074),17.0％(2733/16 074),P＜ 0.01 ].The level of SUA in patients with MS [ (342.3 ± 64.2 ) μ mol/L ] was higher than that of those without MS[ (319.3 ± 67.1 )μ mol/L,P =0.000].Conclusions The prevalence of HUA is increased with age.Multiple factors of dysbolism are clustered in subjects with HUA.There is correlation between SUA and MS. Key words: Hyperuricemia; Metabolic syndrome X; Health examination