Risk factors for the occurrence of hyperuricemia in patients with type 2 diabetes mellitus

Abstract

Objective To investigate the risk factors for the occurrence of hyperuricemia in patients with type 2 diabetes mellitus. Methods The data of 126 patients with type 2 diabetes mellitus admitted to the First Affiliated Hospital of Henan University from July 2016 to July 2018 were retrospectively analyzed. Patients with type 2 diabetes mellitus complicated with hyperuricemia were included in the high uric acid group (n=38). The other patients were included in the normal uric acid group (n=88). The risk factors for the occurrence of hyperuricemia in patients with type 2 diabetes mellitus were analyzed. Results By the analysis of the clinical data from 126 patients with type 2 diabetes mellitus, it was found that age, gender, course of disease and combined hypertension were not associated with the occurrence of hyperuricemia in patients with type 2 diabetes mellitus (P>0.05). Body mass index (BMI), triglyceride (TG), fasting plasan glucose (FPG), glomerular filtration rate (eGFR) and blood urea nitrogen (BUN) were associated with the occurrence of hyperuricemia in patients with type 2 diabetes mellitus (P<0.05). Multivariate logistic regression analysis found that BMI, TG, FPG and BUN were independent risk factors for the occurrence of hyperuricemia in patients with type 2 diabetes mellitus (OR=1.429, 95%CI 1.038-1.967; OR=1.296, 95%CI 1.014-1.655; OR=1.468, 95%CI 1.075-2.005; OR=1.446, 95%CI 1.125-1.859; P<0.05). And eGFR was the protective factor against hyperuricemia in patients with type 2 diabetes mellitus (OR=0.476, 95%CI 0.284-0.798, P<0.05). Conclusions BMI, TG, FPG and BUN are independent risk factors for hyperuricemia in patients with type 2 diabetes mellitus. eGFR is a protective factor against hyperuricemia in patients with type 2 diabetes mellitus. For the above factors, preventive measures should be made to further reduce the incidence of hyperuricemia in patients with type 2 diabetes mellitus. Key words: Type 2 diabetes mellitus; Hyperuricemia; Risk factor