Relationship between the level of serum uric acid and the happening and progression of type 2 diabetic nephropathy with stable blood glucose

Abstract

Objective To investigate the relationship between the level of serum uric acid and the happening and progression of type 2 diabetic nephropathy with stable blood glucose.Methods Thirty cases of simple type 2 diabetes mellitus patients were choosed as the diabetes mellitus (DM) group,30 cases of simple hyperuricemia patients were choosed as the hyperuricemia(HUA) group,30 cases of type 2 diabetes mellitus conbined with hyperuricemia patients were choosed as the diabetes mellitus combined with hyperuricemia(DM-HUA) group,and the other 30 patients of the healthy physical examination department were choosed as normal control (NC) group from the first affiliated hospital of Zhengzhou university.The blood concentration of the creatinine (Cr),blood urea nitrogen(BUN),β2 microglobulin,serum uric acid(SUA),total cholesterol(TC),triglyceride(TG),HDL-C,LDL-C and the urinary albumin to creatinine ratio(ACR) were detected,meanwhile the body mass index(BMI) was calculated,and the statistical analysis was made.Results The DM-HUA group had the higher level of TC,TG,LDL-C,ACR and lower HDL-C than the other three groups,and higher BMI than NC and DM group (P ＜0.05) ; The difference of TC,TG,HDL-C,LDL-C had no significant between the DM and HUA group (P ＞0.05),but had the higher level ofTC,LDL-C,BMI than NC group(P ＜0.05) ; The HUA group had higher concentration of BUN and Cr than NC group (P ＜ 0.05).The multiple linear regression analysis showed that serum uric acid (UA) was the main influence factor of ACR (R2 =0.5027,P ＜0.01).Conclusions ①Hyperuricemia is highly correlated with the dyslipidemia and overweight of the patients; ②Serum uric acid is the main influence factor of ACR.③T2DM with hyperuricemia patients are easier to get diabetic nephropathy,hyperuricemia can promote the happening and progression of the diabetic nephropathy. Key words: Hyperuricemia; Type 2 diabetes mellitus; Diabetic nephropathy; Urinary albumin to creatinine ratio