Correlation study between vitamin D level and glucose metabolism, lipid metabolism, insulin resistance, early secretory function of pancreatic islets in postmenopausal women with type 2 diabetes

Abstract

Objective To investigate correlation between vitamin D and glucose metabolism, lipid metabolism, insulin resistance, early secretory function of pancreatic islets in postmenopausal women with type 2 diabetes. Methods 115 postmenopausal women with type 2 diabetes were selected as observation group.115 postmenopausal women without type 2 diabetes were selected in hospital at same period as control group.All patients received detection of vitamin D, glucose metabolism, lipid metabolism, insulin resistance, early secretory function of pancreatic islets.Correlation between vitamin D and glucose metabolism, lipid metabolism, insulin resistance, early secretory function of pancreatic islets were analyzed. Results Fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, insulin resistance index in the observation group were higher than the control group[(8.5±1.2)mmol/L vs (5.1±0.6)mmol/L, (13.4±1.5)mmol/L vs (7.8±0.7)mmol/L, (8.7±1.1)% vs (5.6±0.5)%, (25.7±1.0)kg/m2 vs (22.3±0.4)kg/m2, (5.6±0.7)mmol/L vs (4.5±0.4)mmol/L, (2.3±0.5)mmol/L vs (1.7±0.3)mmol/L, (3.5±0.6)mmol/L vs (2.2±0.4)mmol/L, (3.6±0.5) vs (2.5±0.4), t=9.667, 10.179, 8.535, 4.524, 5.443, 6.529, 8.909, 7.406, all P<0.05]. High density lipoprotein cholesterol, insulin first secretion phase peak factor, pancreatic islet βcell function index, fasting insulin, vitamin D in the observation group were lower than the control group[(1.0±0.2)mmol/L vs (1.2±0.3)mmol/L, (5.2±1.3) vs (8.4±1.6), (135.8±11.7) vs (194.3±19.2), (4.1±0.9)IU/mL vs (10.8±0.6)IU/mL, (10.8±2.1)ng/L vs (27.4±3.8)ng/L, t=5.087, 9.153, 7.370, 10.414, 18.371, all P<0.05]. Vitamin D was significantly negatively correlated with fasting blood glucose, postprandial 2h blood glucose, glycosylated hemoglobin, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, insulin resistance index(r=-0.537, -0.512, -0.469, -0.387, -0.325, -0.316, -0.372, -0.457, all P<0.05). Vitamin D were significantly positively correlated with high density lipoprotein cholesterol, insulin first secretion phase peak factor, pancreatic islet β cell function index, fasting insulin(r=0.351, 0.418, 0.674, 0.316, all P<0.05). Conclusion Vitamin D deficiency in postmenopausal women with type 2 diabetes may be involved in glucose-lipid metabolism and insulin resistance, but also may be one of the reasons leading to decreasing of early secretory function of pancreatic β cells. Key words: Diabetes, type 2; Vitamin D; Glucose-lipid metabolism; Insulin resistance; Early pancreatic secretion function; Correlation