Clinical investigation of Roux-en-Y gastric bypass surgery for patients with type 2 diabetes mellitus and obesity

Abstract

Objective To investigate the clinical outcome of Roux-en-y gastric bypass surgery (RYGB) on the physiological indexes and insulin resistance of patients with type 2 diabetes mellitus (T2DM) and obesity. Methods From October 2012 to December 2017, 86 patients with T2DM and obesity were enrolled in the present study, who underwent laparoscopic Roux-en-Y gastric bypass surgery. Statistical analysis were performed by using SPSS18.0 software. 6 months and 12 months after operation, measurement data such as Glucose and lipid metabolism indexs, pancreatic beta cell function index (HOMA-beta) and insulin resistance index were expressed as mean±standard deviation and were examined by independent t test. A P value of <0.05 was considered as statistically significant. Results 6 and 12 months after operation, the body weight (BMI) of patients decreased from (33.9±2.6) kg/m2 to (27.7±2.7) kg/m2 and (26.9±3.1) kg/m2 respectively. Indexes of glucose metabolism such as FPG, 2hPG, fasting insulin and HbA1c were decreased significantly after operation (P<0.05). Indexes of lipid metabolism such as TC, TG, LDL-C and HOMA-IR were decreased significantly after operation (P<0.05). However HDL-C and HOMA-β were increased significantly after operation (P<0.05). Conclusion RYGB could improve the glucose and lipid metabolism indexes, increase homa-beta cell function and reduce insulin resistance in T2DM patients with obesity. Key words: Diabetes mellitus; Obesity; Anastomosis, roux-en-Y; Gastric bypass; Insulin resistance