Correlation of thyroid hormone with blood glucose and lipid metabolism in patients with type 2 diabetes mellitus

Abstract

Objective To explore the correlation of thyroid hormone (TH) level with blood glucose and lipid metabolism in patients with type 2 diabetes mellitus . Methods The TH levels of 126 patients with T2DM were analyzed; and their correlation with blood glucose and blood lipids was analyzed. Results The main TH anomaly was increase of TSH, accounting for 11.9%; and the other indicators were all less than 5.0%. TSH, FT3, and TT3 negatively correlated with HbA1c; and the correlation remained after controlling age, gender, disease course, and BMI (P<0.05). FT4, TT3, and TT4 positively correlated with TC and LDL-C; and the correlation remained after controlling age, gender, disease course, BMI, and HbA1c (P<0.05). Conclusions The incidence of hypothyroidism in T2DM patients is significantly higher than other thyroid related diseases. When TH is abnormal, the metabolisms of water, electrolyte, blood glucose, and blood lipid are all influenced in different degrees. TH level has important clinical significance for the assessment, prognosis evaluation, and disease control of T2DM. Key words: Type 2 diabetes mellitus; Thyroid hormones; Blood glucose metabolism; Blood lipid metabolism