Relationship between serum alpha-L-fucosidase level and lipid metabolism in hospitalized patients with type 2 diabetes mellitus in Hetian area of Xinjiang

Juhong Yang ,Abdullah Ablai ,Liyi Zhang ,Ali Abelimi ,Yashengnahong Apiyeti ,Aikebaier Rezeye ,Matilthurson Ibadeti ,Maimaiti Patriculi ,Abibra Reyehanguli ,Zhenzhen Shi ,Abdurexiti Abdumijiti

doi:10.3760/cma.j.issn.1673-4157.2019.05.001

Abstract

Objective To study the characteristics of lipid metabolism and its relationship with serum alpha-L-fucosidase (AFU) level in patients with type 2 diabetes mellitus in Hetian, Xinjiang. Methods A total of 1 000 patients with type 2 diabetes were enrolled in the Department of Internal Medicine, The People′s Hospital of Hetian District in Xinjiang from January to December in 2018, including 456 males and 544 females, with an average age of (54.9±11.3) years. The characteristics of blood lipid metabolism and its relationship with serum AFU were retrospectively analyzed, and the differences between Uygur and Han patients were analyzed. Results The average glycosylated hemoglobin A1c of this group was (9.4±2.3)%, with only 15.8% patients met the target recommended by Chinese Diabetes Society. Only 53.5%patients achieved the goal of control in low density lipoprotein-cholesterol, and about 30% patients achieved the goal of control in total cholesterol, triglyceride and high density lipoprotein-cholesterol (HDL-C). There was no statistical difference between Uygur and Han ethnics. Multiple logistic regression analysis showed that serum total protein (OR=1.038, 95% CI: 1.015-1.062, P=0.001), fasting plasma blood glucose (OR=1.051, 95% CI: 1.023-1.079, P<0.001), apolipoprotein A1(OR=7.830, 95% CI: 2.831-21.654, P<0.001) were positively correlated with AFU, and HDL-C was negatively correlated with AFU (OR=0.312, 95% CI: 0.142-0.684, P=0.004). The level of AFU in Uygur patients was lower than that in Han patients, and the effect was independent of other influencing factors (OR=6.185, 95% CI: 3.087-12.392, P<0.001). Conclusions The percentages of patients obtaining blood glucose and lipid control are not high in type 2 diabetes in Uygur ethnic group in Xinjiang. AFU is closely related to glucose and lipid metabolism in type 2 diabetic patients. Elevated AFU is a risk factor for the decrease of HDL-C in type 2 diabetic patients. Key words: Type 2 diabetes mellitus; Alpha-L-fucosidase; Glucose metabolism; Lipid metabolism

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