Correlation of the plasma homocysteine level and serum apolipoprolion B/apofipoprolion A1 （ ApoB/ApoA1 ） radio with cerebral vascular stenosis in patients with cerebral infarction

Abstract

Objective To investigate the correlation of the plasma homocysteine level and serum B/apoli- poprolionAl（ApoB/ApoA1） radio with cerebral vascular stenosis in patients with cerebral infarction. Methods 184 patients with cerebral infarction experienced cerebral digital substraction angiography （DSA） were selected. Among them, 158 patients with cerebrovascular stenosis and 26 patients without stenosis were included. Three groups were categorized by distribution of artery lesion sites ： isolated intracranial artery stenosis （ n = 48 ）, isolated extracranial artery stenosis（ n = 60 ） co-existing of intracranial and extracranial artery stenosis（ n = 50）. The correlation analysis was made between the levels of Hcy and ApoB/ApoA1 with cerebral vascular stenosis in patients with cerebral infarction. Results （ 1 ） The proportion of subjects with high level of plasma homoeysteine was significantly higher in patients with cerebrovascular stenosis than those without [ （ 16.9 ± 8.1 ） μmoL/L vs （ 8.6 ± 4.6 ） μmol/L, P 〈 0. 001 ;40% vs 0, P 〈 0.01 ]. The proportion of subjects with high level of ApoB and ApoB/ApoA1 ratio was significantly higher in patients with cerebrovascular stenosis than those without ApoB [ （ 1.02± 0.25 ） vs （ 0.86 ± 0. 22 ） g/L, P 〈 0.01 ] , ApoB/ApoA1 ratio [ （ 0.94± 0.50 ） vs （ 0.64 ±0. 21, P 〈 0.01 ） ]. （ 2 ） For the different groups of artery lesion sites, the proportion of subjects with high level of plasma homocysteine was not significantly different[ （16.1 ± 8.5 ）mmol/ L, （ 17.0 ± 8.9 ） mmoL/L, （ 16.7 ± 8.7 ） mmol/L, P 〉 0. 05 ], the proportion of subjects with ApoB/ApoA1 ratio was not significantly different [ 0.98 ± 0.45,0.93 ± 0.48,0.96 ± 0.50, P 〉 0. 05 ]. （ 3 ） Based on muhivariable stepwise Logistic regression model, the increased level of Hey （ OR = 1. 146,95 % CI ： 1. 021 - 1. 287 ; P = 0. 021 ） , the increased level of ApoB/ApoAl（ OR =4.71,95% CI：I. 70 - 14.20,P =0.005） ,the increased level of ApoB（ OR =4.50,95% CI 为 1.62 ±12.80,P = 0.007 ）, the increased level of Cho （ OR = 2. 406 ; 95% CI ： 1. 145 - 5. 055 ; P = 0.023 ）, the decresed level of HDL（OR =0.089,95%CI：0.014 -0.551 ,P =0.017）were all risk factors. Conclusion High level of plasma homocysteine and ApoB/ApoA1 were both independent risk factors for cerebral vascular stenosis. Key words: Cerebral infarction; Hyperhomocysteinemia; Apolipoprolion ; Vascular Diseases