Abstract
Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11–14 years) were randomly selected from middle schools in Kuwait. Obesity was classified by the BMI-for-age based on the WHO growth charts. Plasma ANGPTL5, HsCRP, and Ox-LDL were measured using ELISA. The prevalence of overweight and obesity was 20.65% and 33.18%, respectively. Mean (SD) plasma ANGPTL5 levels were significantly higher in obese, compared with overweight and normal-weight adolescents (23.05 (8.79) vs 18.39 (7.08) ng/mL, and 18.26 (6.95) ng/ml, respectively). ANGPTL5 was positively associated with both HsCRP (ρ=0.27, p < 0.001) and Ox-LDL (ρ = 0.24, p < 0.001). In Conclusion, ANGPTL5 levels are elevated in obese adolescents and are associated with cardiovascular disease risk factors, HsCRP and Ox-LDL. The use of ANGPTL5 as a powerful diagnostic and prognostic tool in obesity and metabolic diseases needs to be further evaluated.
Highlights
Angiopoietin-like protein 5 (ANGPTL5) is a member of the angiopoietin-like proteins (ANGPTLs) family
The authors demonstrated that circulating ANGPTL8 levels were positively associated with triglycerides (TG), whereas ANGPTL3 levels were associated with fasting insulin and the homeostasis model assessment of insulin resistance (HOMA-IR)
One of the main pathways that are dysregulated in cardiovascular diseases and diabetes are the ANGPTL proteins
Summary
Angiopoietin-like protein 5 (ANGPTL5) is a member of the angiopoietin-like proteins (ANGPTLs) family. Eight members have been described so far (ANGPTL1 through ANGPTL8), and have been shown to have various physiological functions in lipid and glucose metabolism, inflammation, hematopoiesis, angiogenesis and cancer[4,5,6,7] They are differentially expressed in multiple tissues: for example, while ANGPTL3 is exclusively expressed in the liver and kidney, ANGPTL7 is expressed in the eye. Many studies have reported changes in circulating levels of ANGPTL family proteins members in obesity and diabetes, as well as other metabolic diseases. We aimed to compare the circulating level of ANGPTL5 between obese, overweight and normal-weight adolescents, and to investigate the association between ANGPTL5 and well-established CVD risk factors, namely HsCRP and oxidized low-density lipoprotein (Ox-LDL). Like other ANGPTL proteins, plasma ANGPTL5 levels are positively associated with obesity, HsCRP, and Ox-LDL
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