Correlation of Arterial stiffness and early renal damage in patients with type 2 diabetes mellitus

Abstract

Objective To investigate the relationship between early diabetic nephropathy and arterial stiffness in patients with type 2 diabetes mellitus. Methods The clinical data of one hundred twenty patients with T2DM were collected for retrospective study. The patients with T2DM were divided into an early diabetic nephropathy group (Group A)and a non-early diabetic nephropathy(Group B)according to the albuminuria to creatinine ratio(ACR)of first morning urine. Then compared the difference of the arterial stiffness between the two groups. Results An independent-sample T test was used for analysis. The brachial-ankle pulse wave velocity(baPWV)in group A and group B was(1 827.3±450.2)cm/s and(1 634.5±285.8)cm/s,respectively, which was statistically significance(t=2.164,P <0.05). Logistic regression analysis, in which baPWV was regarded as dependent variable, while age,blood pressure, ACR, and blood urea nitrogen(BUN)were independent variables, showed that age,systolic pressure, ACR,and BUN had an influence on the result of baPWV. Conclusion The patients with T2DM with arterial stiffness are prone to early diabetic nephropathy. Therefore, dectection of arterial stiffness maybe an effective measure to evaluate the renal function of patients with T2DM, and make an intervention as soon as possible. Key words: Diabetes mellitus, type 2; Arterial stiffness; Renal injury; Albuminuria; Creatinine